Vivimed 333mg/50mg - tablets

Vivimed 333 mg/50 mg - Tablets are a combination of paracetamol, an analgesic, antipyretic agent and caffeine.

Application

What are VIVIMED 333 MG/50 MG - TABLES AND WHAT ARE THEY USED FOR?

Vivimed 333 mg/50 mg - Tablets are a combination of paracetamol, an analgesic, antipyretic agent and caffeine.

Vivimed 333 mg/50 mg - Tablets are used for the symptomatic treatment of acute, short-lasting, non-inflammatory mild to moderate pain (such as headache, toothache, period pain).

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How is it used?

What are Vivimed 333 mg/50 mg - tablets and what are they used for?

Vivimed 333 mg/50 mg - Tablets are a combination of paracetamol, an analgesic, antipyretic agent and caffeine.
Vivimed 333 mg/50 mg - Tablets are used for the symptomatic treatment of acute, short-lasting, non-inflammatory mild to moderate pain (such as headache, toothache, period pain).

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What should you be aware of before taking this medicine?

What should you be aware of before taking Vivimed 333 mg/50 mg - Tablets?

Vivimed 333 mg/50 mg - Tablets must not be taken
- if you are hypersensitive (allergic) to the active substances paracetamol, caffeine or any of the other ingredients of this medicine listed in section 6.
- if you have a severe impairment of liver function.
- if you have a genetic deficiency of glucose-6-phosphate dehydrogenase (a hereditary metabolic disorder).
- in the case of excessive or regular alcohol consumption.
- by children under 12 years of age.
Special caution is required when taking Vivimed 333 mg/50 mg - Tablets:
If your symptoms worsen or do not improve after 3 days, if you have a high fever or if there are signs of a (second) infection, you must consult a doctor.
Warnings and precautions
Please talk to your doctor or pharmacist before taking Vivimed 333 mg/50 mg - Tablets.
You must not take Vivimed 333 mg/50 mg - Tablets until you have consulted your doctor,
- if you have impaired liver function, such as hepatitis or a congenital disease with jaundice (Gilbert's syndrome or Meulengracht's disease),
- if your kidneys are already damaged,
- if you have hyperthyroidism,
- if you have cardiac arrhythmia,
- if you have anxiety disorders,
- if you regularly suffer from malnutrition or undernourishment,
. in the case of an increase and increased excretion of urinary stone-forming substances (oxalic acid) in the urine. In principle, Vivimed 333 mg/50 mg tablets should only be used for a few days and not for a longer period or in higher doses without medical or dental advice.
Exceeding the recommended dose can lead to kidney damage and very severe liver damage. In this case, immediate medical treatment is required (see section 3).
To prevent the risk of overdose, you should be sure that other medicines you use at the same time do not contain paracetamol. Please ask your doctor or pharmacist if any medicines you are taking at the same time contain paracetamol and if the dosage needs to be adjusted.
Without a doctor's advice, Vivimed 333 mg/50 mg tablets must not be taken for more than 10 days in a month, for more than 3 days in a row and not in an increased dose. Prolonged use, high doses or regular use may cause severe liver and kidney damage.
General information on painkillers
Painkiller headache
Prolonged high-dose use of painkillers not in accordance with their intended purpose may cause headaches caused by the painkiller itself. These must therefore not be treated by increased doses of the drug.
Kidney damage
The habitual use of painkillers, especially when several analgesic agents are combined, can lead to permanent kidney damage with the risk of kidney failure (nephropathy).
Discontinuation of painkillers
If painkillers are discontinued abruptly after prolonged high-dose, non-intended use, headaches as well as tiredness, muscle pain, nervousness and other complaints such as sweating, dizziness, trembling, palpitations may occur. These symptoms disappear within a few days. Until then, painkillers should not be taken again and should not be taken again without medical advice. Medicines containing caffeine should only be taken in low doses in the case of
- irregular heartbeat with increased pulse rate,
- liver disease (cirrhosis of the liver),
- hyperthyroidism,
- anxiety disorder,
- stomach and duodenal ulcer.
Taking Vivimed 333 mg/50 mg - Tablets with other medicines
Inform your doctor or pharmacist if you are taking/using, have recently taken/used or do not intend to take/use any other medicines.
Interactions of paracetamol (active substance of Vivimed 333 mg/50 mg - Tablets) are
possible with
- anticoagulant medicines: enhancement of the effect of oral anticoagulant medicines, especially with prolonged use (more than one week), with only an insignificant effect if given irregularly.
- Salicylamides (certain medicines for pain and fever): May lead to a delay in the excretion of paracetamol and accumulation effects. (Also promote formation of the liver-damaging breakdown product).
- Drugs for gout such as probenecid: If probenecid is taken at the same time, the dose of Vivimed 333 mg/50 mg - Tablets should be reduced as the breakdown of paracetamol may be slowed.
- Enhancement of the formation of harmful breakdown products by drugs that stimulate liver metabolism (e.g. barbiturates (sleeping pills and sedatives), carbamazepine and phenytoin (drugs used to treat epilepsy), rifampicin (drugs used to treat tuberculosis and other rare bacterial diseases)) and other drugs that may damage the liver.
In some circumstances, liver damage may occur if taken at the same time as Vivimed 333 mg/50 mg - Tablets.
- Medicinal products that accelerate gastric emptying, such as metoclopramide, may accelerate the absorption and onset of action of paracetamol.
- Drugs to lower elevated blood lipid levels such as cholestyramine may reduce the absorption and therefore the effectiveness of paracetamol.
- Drugs for HIV infection such as zidovudine. Decrease in white blood cells (neutropenia) is increased. Vivimed 333 mg/50 mg tablets should therefore only be taken at the same time as zidovudine on medical advice.
- Nizatidine (for the treatment of stomach and duodenal ulcers): Leads to increased blood levels of paracetamol.
- Cisapride (certain medicines used to treat gastrointestinal symptoms): Increases the availability of paracetamol.
- Lamotrigine (certain medicines for epilepsy or depression): It decreases the availability of lamotrigine.
- Medicines that cause the stomach to empty more slowly, such as propantheline. It may delay the absorption and onset of action of paracetamol.
- Chloramphenicol (certain antibiotic = medicine against infections): The degradation of the antibiotic is delayed (increased side effects possible).
Effects of taking Vivimed 333 mg/50 mg - Tablets on laboratory tests
Uric acid determination and blood sugar determination may be affected.
High doses of levodopa (certain medicines used to treat Parkinson's disease) may interact with the chemical detection of paracetamol in plasma and give a false positive paracetamol value.
-Interactions of caffeine (active ingredient of Vivimed 333 mg/50 mg - Tablets) are possible with - accelerates the absorption of ergotamine (certain medicines used to treat
migraines) into the body.
- Simultaneous alcohol intake increases the liver-damaging effect of paracetamol.
- In the case of substances with a broad spectrum of action, the interactions may vary in detail and cannot be predicted (e.g. in the case of tranquillisers of the benzodiazepinetype).
- reduces the sleep-promoting effect of certain sleeping pills such as barbiturates, certain medicines for allergies such as antihistamines etc.
- enhances the heart rate-increasing effect of certain circulatory medicines such as sympathomimetics, certain thyroid medicines such as thyroxine, etc.
- can increase the analgesic effect of paracetamol and certain painkillers known as non-steroidal anti-inflammatory drugs.
- reduces the excretion of certain medicines used to treat bronchial asthma such as theophylline.
- increases the potential for dependence on substances of the ephedrine drug type (vasoconstrictors).
- Oral contraceptives (the pill"), certain medicines used to treat stomach ulcers such as cimetidine and certain alcohol depressants such as disulfiram decrease the breakdown of caffeine in the liver.
- Certain sleeping pills and sedatives such as barbiturates and smoking accelerate caffeine breakdown in the liver.
- Certain antibiotics (drugs used to treat infections (gyrase inhibitors of the quinolone carboxylic acid type)) can delay the excretion of caffeine and its breakdown product paraxanthine.
When taking Vivimed 333 mg/50 mg - Tablets together with food and drinks
Vivimed 333 mg/50 mg - Tablets must not be taken together with alcohol. Pregnancy and breast-feeding
If you are pregnant or breast-feeding, or if you suspect you may be pregnant or intend to become pregnant, ask your doctor or pharmacist
for advice before taking this medicine.
Pregnancy
If necessary, Vivimed 333 mg/50 mg - Tablets may be used during pregnancy. You should use the lowest possible dose that will relieve your pain and/or fever and you should use the medicine for the shortest possible period of time. Contact your doctor if the pain and/or fever are not relieved or if you need to take the medicine more often.
Lactation
Paracetamol and caffeine, the active substances of Vivimed 333 mg/50 mg - Tablets, pass into breast milk. The infant's condition and behaviour may be affected by caffeine absorbed with the breast milk. Adverse effects on the infant due to
paracetamol have not been reported to date. In the case of short-term use of the recommended dose, interruption of breast-feeding will not usually be necessary. For prolonged use or taking higher doses, you should stop breast-feeding.
Driving and ability to operate machinery
There are no known effects of Vivimed 333 mg/50 mg - Tablets on driving and ability to operate machinery.
Despite this, caution is always advised after taking a painkiller because of possible side effects.
Vivimed 333 mg/50 mg - Tablets contains sodium
This medicine contains less than 1 mmol (23 mg) of sodium per unit dose, which means it is
nearly "sodium-free".

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How should the medicine be taken?

How should Vivimed 333 mg/50 mg tablets be taken?

Always take Vivimed 333 mg/50 mg - Tablets exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are not quite sure. In principle, painkillers should be dosed as low as necessary for a sufficient effect and only used for as long as absolutely necessary to keep the risk of the occurrence of undesirable effects as low as possible.
The dosage is based on the information in the following table. The interval between two doses should be at least 6 hours.
Body weight
Single dose
max. Daily dose
age
number of tablets
adolescents from 12
1 tablet
4 tablets
years of age with at least
(333 mg paracetamol and 50 mg
(corresponding to 1332 mg paracetamol and 43 kg body weight
caffeine)
200 mg caffeine)
and adults

Method of use
Take the tablets unchewed with plenty of non-alcoholic liquid (preferably a glass of drinking water).
Duration of use
Do not take Vivimed 333 mg/50 mg tablets for more than 3 days without medical or dental advice.
If the symptoms persist for more than 3 days, a doctor must be consulted.
Special patient groups
Liver dysfunction and mild impairment of kidney function
In patients with liver or kidney dysfunction and Gilbert's syndrome (a congenital condition), the dose must be reduced or the interval between doses extended.
Severe impairment of renal function
In cases of severe impairment of renal function (creatinine clearance < 10 ml/min), a dosing interval of at least 8 hours must be observed.
Older patients
No special dose adjustment based on age is required. In case of underweight and/or organ dysfunction, please follow appropriate instructions.
Children under 12 years of age
There is insufficient evidence to support the use of Vivimed 333 mg/50 mg tablets in children under 12 years of age.
If you have taken a larger amount of Vivimed 333 mg/50 mg - Tablets than you should
The symptoms of an overdose of Vivimed 333 mg/50 mg - Tablets are made up of the signs of overdose with the individual substances.
As a rule, side effects of a paracetamol overdose occur within 24 hours: Nausea, vomiting, loss of appetite, pallor and abdominal pain. Despite improvement of the general condition on the 2nd day, progressive and severe damage to the liver may occur.
There is a risk of poisoning especially in elderly people, small children, persons with liver diseases, regular alcohol abuse, regular malnutrition or undernourishment and in the case of simultaneous intake of medicinal products which have an effect on liver function.
In the event of an overdose with caffeine, complaints affecting the brain in particular may be caused, e.g. seizures, restlessness, agitation, trembling and cardiovascular reactions such as palpitations,
pain in the heart area.
Inform a doctor immediately if you have taken a larger amount of Vivimed 333 mg/50 mg - Tablets than recommended.
If you forget to take Vivimed 333 mg/50 mg - Tablets
Do not take twice the amount if you have forgotten to take it before. Continue taking the medicine as described in the dosing instructions.
If you stop taking Vivimed 333 mg/50 mg - Tablets
If you have any further questions on the use of this medicine, ask your doctor or pharmacist

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What side effects may occur?

How to store Vivimed 333 mg/50 mg - Tablets?

Keep this medicine out of the reach of children.
Do not store above 25 °C.
You must not use this medicinal product after the expiry date which is stated on the outer carton and blister after "used by/usable until". The expiry date refers to the last day of the month.
Never dispose of medicines through the waste water (e.g. not through the toilet or sink). Ask your pharmacy how to dispose of the medicine when you are no longer using it. By doing so, you are helping to protect the environment.

Special storage instructions

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HOW TO STORE VIVIMED 333 MG/50 MG - TABLETS?

Store medicines out of the reach of children.

You must not use the medicine after the expiry date which is stated on the outer carton and blister. The expiry date refers to the last day of the month.

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Special notes on contents

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Additional information

What Vivimed 333 mg/50 mg - Tablets contain
The active ingredients are: Paracetamol and Caffeine.
1 tablet contains 333 mg paracetamol and 50 mg caffeine.
The other ingredients are: Microcrystalline cellulose, carboxymethyl starch sodium (type A), povidone (K-28-30), magnesium stearate, purified water.
What Vivimed 333 mg/50 mg - Tablets look like and contents of the pack
Vivimed 333 mg/50 mg - Tablets are white, round tablets with a break notch and "Vivimed" embossed on one side.
The break notch is only for dividing the tablet for easier swallowing and not for dividing into equal doses.
Vivimed 333 mg/50 mg - Tablets are available in packs of 30 tablets.

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