Nurofen 200 mg Lemon melting tablets

Nurofen contains 200 mg ibuprofen.

Application

What is Nurofen and what is it used for?

Nurofen contains 200 mg of ibuprofen. Ibuprofen belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). These medicines affect the body's response to pain, swelling and increased temperature.

Nurofen is used for:
symptomatic relief of mild to moderate pain such as headache, toothache and period pain.
reduction of fever

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How is it applied?

What is Nurofen and what is it used for?

Nurofen contains 200 mg of ibuprofen. Ibuprofen belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). These medicines affect the body's response to pain, swelling and increased temperature.

Nurofen is used for:

• symptomatic relief of mild to moderate pain such as headache, toothache and period pain
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• Lowering fever
• Nurofen is used in adults and adolescents over 12 years of age
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If the complaints do not get better or even get worse, you need to talk to a doctor:

• for adolescents after 3 days
• In adults after 3 days of fever or after 4 days with pain.

What should you pay attention to before taking it?

What should you be aware of before taking Nurofen?

Nurofen must not be taken,

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• If you are allergic to ibuprofen or any of the other ingredients of this medicine listed in section 6,
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• If you have ever suffered from shortness of breath, asthma, runny nose, swelling of your face and/or hands or hives after previously taking ibuprofen, acetylsalicylic acid or similar painkillers (NSAIDs),
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• If you have severe liver or kidney dysfunction or heart failure,
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• If you have or have had stomach ulcers or stomach bleeding (at least 2 episodes),
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• If you have a history of gastrointestinal bleeding or perforation in connection with therapy with non-steroidal anti-inflammatory drugs (NSAIDs).
• If you have brain bleeding (cerebrovascular haemorrhage) or other active bleeding,
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• if you have unexplained blood formation disorders,
• If you are seriously dehydrated (caused by vomiting, diarrhoea or insufficient fluid intake),
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• during the last three months of pregnancy (see below).

Warnings and precautions.
Please talk to your doctor or pharmacist before taking Nurofen,

• for certain skin diseases (systemic lupus erythematosus (SLE), or certain
  connective tissue diseases (mixed collagenosis),
• If you have severe skin reactions such as exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis. At the first sign of skin rashes, mucosal lesions or other signs of a hypersensitivity reaction, Nurofen should be discontinued immediately,
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• If you have certain hereditary disorders in blood formation (e.g. acute intermittent porphyria),
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• if you suffer from blood clotting disorders,
• If you suffer or have suffered from stomach and intestinal diseases (ulcerative colitis, Crohn's disease),
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• in the case of reduced kidney function,
• in liver dysfunction,
• if you are trying to get pregnant,
• If you suffer or have suffered from asthma or allergic reactions, shortness of breath may occur,
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• If you suffer from hay fever, nasal polyps or chronic obstructive respiratory disease, the risk of an allergic reaction is greater. The allergic reactions can occur as asthma attacks (so-called painkiller asthma), Quincke's oedema or hives,
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• Anti-inflammatories/painkillers such as ibuprofen may be associated with a slightly increased risk of heart attack or stroke, especially when used in high doses. Do not exceed the recommended dose or duration of treatment,
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• The use of Nurofen during chickenpox is not recommended,
• If you are taking Nurofen for a long time, your liver values, kidney function and blood count should be monitored regularly,
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• Adverse effects can be minimised by taking the smallest effective dose for the shortest possible time,
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• Older people may experience side effects more often,
• In general, the habitual use of (various types of)
  painkillers can lead to permanent kidney damage. Physical stress combined with salt loss and dehydration can increase the risk. This should be avoided,
• If you take any kind of painkiller for headaches for a long time, they can get worse. If this is the case or you suspect it, you should seek medical advice and stop the treatment. In patients who have frequent or daily headaches despite (or because of) regular use of headache medication, the diagnosis of analgesic headache should be considered,
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• Simultaneous use of Nurofen with other NSAIDs, including COX-2 inhibitors (cyclooxigenase-2 inhibitors), increases the risk of side effects (see section "Use with other medicines") and should therefore be avoided,
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• Directly after a major surgical intervention, special medical supervision is necessary,
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• NSAIDs can mask the symptoms of infection or fever.
• You should discuss your treatment with your doctor or pharmacist before taking Nurofen Meltlets if you
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have heart disease, including heart failure and angina (chest pain), or have had a heart attack, bypass surgery, peripheral arterial disease (blood flow problems in the legs or feet due to narrowed or blocked arteries) or any type of stroke (including mini-stroke or transient ischaemic attack, "TIA"). You may have had a heart attack, bypass surgery, peripheral arterial disease (blood flow problems in the legs or feet due to narrowed or blocked arteries) or any type of stroke (including mini-stroke or transient ischaemic attack, "TIA").
• Have high blood pressure, diabetes or high cholesterol, or a family history of heart disease or stroke, or if you are a smoker
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Children and adolescents

• There is a risk of renal dysfunction in dehydrated adolescents,

Taking Nurofen with other medicines.
Inform your doctor or pharmacist if you are taking/using, have recently taken/used or intend to take/use any other medicines.

Nurofen may interfere with or be interfered with by other medicines. For example:

• Medicines that have an anticoagulant effect (i.e. thin the blood/prevent blood clotting, e.g. acetylsalicylic acid, warfarin, ticlopidine)
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• Medicines that lower high blood pressure (ACE inhibitors such as captopril, beta blockers such as atenolol-containing medicines, angiotensin II receptor antagonists such as losartan)
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Some other medicines may also interfere with treatment with Nurofen or may themselves be affected by such treatment. You should therefore always seek the advice of your doctor or pharmacist before using Nurofen with other medicines.

This applies in particular to taking the following medicines:

• Other NSAIDs (anti-inflammatories and painkillers), including cyclooxigenase-2 inhibitors, as this may increase the risk of stomach and intestinal ulcers or bleeding,
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• Digoxin (for heart failure), as the effect of digoxin may be increased,
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• Glucocorticoids (medicines containing cortisone or cortisone-like substances), as this may increase the risk of stomach and intestinal ulcers or bleeding,
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• Thrombocyte aggregation inhibitors, as this can increase the risk of bleeding,
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• Acetylsalicylic acid (low dose), as the blood-thinning effect may be reduced,
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• Medicines to thin the blood (such as warfarin), as ibuprofen can increase the blood-thinning effect of these medicines,
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• Phenytoin (against epilepsy), as the effect of phenytoin may be increased,
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• Selective serotonin reuptake inhibitors (medicines for depression), as these may increase the risk of gastrointestinal bleeding,
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• Lithium (a medicine for manic-depressive illness and depression), as the effect of lithium may be increased,
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• Probenecid and sulfinpyrazone (medicines against gout), as this can slow down the excretion of ibuprofen,
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• Medicines for high blood pressure and drainage tablets, as ibuprofen can weaken the effect of these medicines, possibly resulting in an increased risk to the kidneys,
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• Potassium-saving diuretics, as this can cause hyperkalaemia (too much potassium in the blood)
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• Methotrexate (a medicine against cancer or rheumatism), as the effect of methotrexate may be increased,
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• Tacrolimus and cyclosporine (immunosuppressive drugs), as this may cause kidney damage,
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• Zidovudine (a medicine used to treat HIV/AIDS). In HIV-positive haemophilia patients ("haemophiliacs"), the risk of joint bleeding (haemarthrosis) or bleeding leading to swelling may be increased,
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• Sulphonylureas (medicines against diabetes), as interactions are possible,
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• Chinolone antibiotics, as the risk for seizures is increased.
• CYP2C9 inhibitors, as concomitant administration of ibuprofen and CYP2C9 inhibitors may increase exposure to ibuprofen (CYP2C9 substrate). In a study with voriconazole and fluconazole (CYP2C9 inhibitors), exposure to S(+)-ibuprofen was found to be increased by approximately 80 - 100 %. A reduction in the dose of ibuprofen should be considered if potent CYP2C9 inhibitors are administered concomitantly, especially if high doses of ibuprofen are taken together with either voriconazole or fluconazole.

Taking Nurofen with food and drink.
Patients with a sensitive stomach are advised to take Nurofen with a meal.

Pregnancy, lactation and reproductive capacity.

Pregnancy
This medicine must not be taken during the last 3 months of pregnancy. Do not take this medicine during the first 6 months of pregnancy unless otherwise prescribed by your doctor.

Breastfeeding time
The active substance ibuprofen passes into breast milk in very low concentrations, but can be taken during breast-feeding if the recommended dose is observed and it is used for the shortest possible time.

Procreative capacity
Do not take this medicine if you want to become pregnant.

If you are pregnant or breast-feeding, or if you suspect you may be pregnant or intend to become pregnant, ask your doctor or pharmacist for advice before taking this medicine.

Driving ability and ability to operate machinery.
If this medicine is taken for a short time, no or negligible effect on the ability to drive or operate machinery is expected.
Nurofen contains aspartame.
Nurofen contains aspartame, a source of phenylalanine, which may be harmful to patients with phenylketonuria.

How should the medicine be taken?

How to take Nurofen?

Nurofen must not be taken by children under 12 years of age.
Young people
If young people need to take this medicine for more than 3 days or if symptoms get worse, medical advice should be sought.

Adults
If your symptoms get worse or do not improve after 3 days (for fever) or after 4 days (for pain), you should see a doctor.
Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

The recommended dose is:
age one dose
total daily dose<./strong>
(Oral tablets)
(Oral tablets).
Adolescents over
1-2 initial dose 1-2 melting tablets (200 mg to 400 mg
12 years and
ibuprofen), then if necessary 1 or 2 adult
melting tablets (200 mg or 400 mg ibuprofen) every 4-6 hours. Do not take more than 6 melting tablets (1200 mg ibuprofen) in 24 hours.

To take
Let the melting tablet dissolve on the tongue and swallow the dissolved melting tablet mass. Additional fluid intake is not necessary.

Consult your doctor or pharmacist if you have the impression that the effect of Nurofen is insufficient or stronger than you expect.

If you have taken more Nurofen than you should
.If you have taken more Nurofen than you should, or if children have accidentally taken the medicine, always contact a doctor or hospital near you for an assessment of the risk and advice on further treatment.

Symptoms may include nausea, stomach pain, vomiting (possibly including blood), gastrointestinal bleeding, headache, ringing in the ears (tinnitus), confusion, eye tremor (nystagmus), or rarely diarrhoea.
In addition, high doses have been reported to cause rotary vertigo, weakness and dizziness, drowsiness, blurred vision, low blood pressure, chest pain, palpitations, agitation, disorientation,
coma, convulsions (especially in children), unconsciousness, increased blood potassium level
(hyperkalemia), acute renal failure, liver damage, blood in the urine, chills, respiratory depression, increased prothrombin time/INR.(hyperkalaemia), increased prothrombin time/INR, acute renal failure, liver damage, blood in the urine, freezing, respiratory depression, cyanosis, worsening of asthma in asthmatics and breathing problems.

If you have any further questions about taking this medicine, ask your doctor or pharmacist.

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What are the possible side effects?

How should Nurofen be kept?

Do not store above 25 °C.
Keep this medicine out of the reach of children.
Do not use this medicine after the expiry date which is stated on the carton and blister after "EXP: or EXP:". The expiry date refers to the last day of the month indicated.

Do not dispose of medicines in waste water or household waste. Ask your pharmacist how to dispose of the medicine when you stop using it. In doing so, they contribute to the protection of the environment.

Special instructions for storage

How should Nurofen be kept?

Keep this medicine out of the reach of children.

Do not use this medicine after the expiry date which is stated on the carton and blister after ,,EXP: or EXP:". The expiry date refers to the last day of the month indicated.
Do not store above 25°C.

Do not dispose of medicines in waste water or household waste. Ask your pharmacist how to dispose of the medicine when you stop using it. In doing so, they contribute to the protection of the environment.

Special notes on the content

Contents of the pack and other information

What Nurofen contains
The active substance is ibuprofen.
Each meltable tablet contains 200 mg ibuprofen.

The other ingredients are: Ethyl cellulose, precipitated silicon dioxide, hypromellose, mannitol, aspartame (E 951), croscarmellose sodium, magnesium stearate, flavouring (lemon).

What Nurofen looks like and contents of the pack
The melted tablets are white to whitish, round tablets with a characteristic lemon smell. The melting tablets are available in packs of 4, 6, 10, 12, 18, 20, 24, 30, 36, 40 and 48 melting tablets.

Not all pack sizes may be marketed.

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